Mutant KRAS peptide vaccine with dual checkpoint blockade in metastatic colorectal cancer: a phase I trial
Hejia Henry Wang, Amanda L. Huff, S. Daniel Haldar, Maureen Berg, Christopher Thoburn, Thatcher R. Heumann, Robert A. Anders, Benjamin Barrett, Katherine M. Bever, Michael J. Pishvaian, Valerie Lee, Dung T. Le, Eric S. Christenson, Marina Baretti, Mark Yarchoan, Daniel Laheru, Amy Thomas, Jennifer N. Durham, Julie M. Nauroth, Jiayun Lu, Hao Wang, Elizabeth M. Jaffee, Nilofer S. Azad, Neeha Zaidi · 2026
Read Mutant KRAS peptide vaccine with dual checkpoint blockade in metastatic colorectal cancer: a phase I trial by Hejia Henry Wang, Amanda L. Huff, S. Daniel Haldar, Maureen Berg, Christopher Thoburn, Thatcher R. Heumann, Robert A. Anders, Benjamin Barrett, Katherine M. Bever, Michael J. Pishvaian, Valerie Lee, Dung T. Le, Eric S. Christenson, Marina Baretti, Mark Yarchoan, Daniel Laheru, Amy Thomas, Jennifer N. Durham, Julie M. Nauroth, Jiayun Lu, Hao Wang, Elizabeth M. Jaffee, Nilofer S. Azad, Neeha Zaidi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13444141.txt.
Description
Hejia Henry Wang and colleagues test a mutant KRAS peptide vaccine with twin immune drugs in metastatic colon cancer in a 2026 trial. These tumors, stable under standard gene checks, shrug off brake-freeing drugs alone. KRAS faults, found in about 40 percent of such cancers, can mint targets that vaccines teach T cells to hunt.
Thirteen pretreated patients took the pooled vaccine, which covers six KRAS faults, plus nivolumab and ipilimumab. Both prime aims, safety and immune spark within 17 weeks, were met in the run. Vaccine-linked harms stayed grade 1 or 2 in all cases. Tumor-hunting T cells rose in 8 of 12 checked patients on direct tests, and in all 12 after lab growth. The team backs wider trials of the pairing.
Catalog record
| CREATOR | Hejia Henry Wang, Amanda L. Huff, S. Daniel Haldar, Maureen Berg, Christopher Thoburn, Thatcher R. Heumann, Robert A. Anders, Benjamin Barrett, Katherine M. Bever, Michael J. Pishvaian, Valerie Lee, Dung T. Le, Eric S. Christenson, Marina Baretti, Mark Yarchoan, Daniel Laheru, Amy Thomas, Jennifer N. Durham, Julie M. Nauroth, Jiayun Lu, Hao Wang, Elizabeth M. Jaffee, Nilofer S. Azad, Neeha Zaidi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70651 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |