C/EBPγ induces epithelial-mesenchymal transition and facilitates DNA double-strand break repair in lung adenocarcinoma cells
Minoru Terashima, Ryusuke Suzuki, Kusuma Suphakhong, Tatsunori Nishimura, Eerdunduleng, Takahisa Takino, Shin-Ichi Horike, Takumi Nishiuchi, Shoichiro Tange, Akihiko Ishimura, Dominic C Voon, Goro Sashida, Takeshi Suzuki · 2026
Read C/EBPγ induces epithelial-mesenchymal transition and facilitates DNA double-strand break repair in lung adenocarcinoma cells by Minoru Terashima, Ryusuke Suzuki, Kusuma Suphakhong, Tatsunori Nishimura, Eerdunduleng, Takahisa Takino, Shin-Ichi Horike, Takumi Nishiuchi, Shoichiro Tange, Akihiko Ishimura, Dominic C Voon, Goro Sashida, Takeshi Suzuki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13443842.txt.
Description
Minoru Terashima and colleagues identify a 2026 mechanism by which the transcription factor C/EBPγ pushes lung adenocarcinoma cells toward a mobile, invasive state while also boosting DNA repair. The team mapped broad histone marks tied to cell identity, then tested the factor by adding it, silencing it, and tracing its protein partners.
Adding C/EBPγ produced mesenchymal shapes and gene patterns, while silencing it blunted the transition. Its leucine zipper domain, not its DNA-binding domain, proved essential, and partners included C/EBPβ plus the repair factors XRCC5 and XRCC6. By blocking a suppressive partner and recruiting repair proteins to breaks, the factor may foster drug resistance, a link worth pursuing for therapy.
Catalog record
| CREATOR | Minoru Terashima, Ryusuke Suzuki, Kusuma Suphakhong, Tatsunori Nishimura, Eerdunduleng, Takahisa Takino, Shin-Ichi Horike, Takumi Nishiuchi, Shoichiro Tange, Akihiko Ishimura, Dominic C Voon, Goro Sashida, Takeshi Suzuki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |