First evidence for isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential
Ekkaphot Khongkla, Panitch Boonsnongcheep, Pipob Suwanchaikasem, Kornkanok Promthep, Monruedee Srisaisup, Theptharin Charuraksa, Pannaphan Makarathut, Banthit Chetsawang · 2026
Read First evidence for isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential by Ekkaphot Khongkla, Panitch Boonsnongcheep, Pipob Suwanchaikasem, Kornkanok Promthep, Monruedee Srisaisup, Theptharin Charuraksa, Pannaphan Makarathut, Banthit Chetsawang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13443643.txt.
Description
Ekkaphot Khongkla and coauthors report the first 2026 isolation and testing of nanovesicles from Bacopa monnieri, a healing plant prized for its chemistry but never before mined for these tiny carriers. The team mapped the vesicles' cargo by mass spectrometry and protein analysis, then tested them against neuroblastoma cells in the lab.
The vesicles ran about 112 nanometers across, carried mainly triterpenoids and triterpene saponins plus the antioxidant enzyme superoxide dismutase, and were taken up by tumor cells, clustering near the nucleus. They suppressed neuroblastoma growth and altered cell shape. The work opens a plant-based route to cancer nanotherapy, though animal and safety studies must follow.
Catalog record
| CREATOR | Ekkaphot Khongkla, Panitch Boonsnongcheep, Pipob Suwanchaikasem, Kornkanok Promthep, Monruedee Srisaisup, Theptharin Charuraksa, Pannaphan Makarathut, Banthit Chetsawang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |