SAPCD2 phosphorylation modulates astral microtubule stability to control spindle orientation
Shuang Chen, Ying Hong, Yaping Fang, Mingxuan Li, Jianhong Xia, Jikai Wen, Feiyang Dai, Yuekai Li, Wandi Bu, Michael S. Y. Huen, Jun Jiang, Yiqun Deng · 2026
Read SAPCD2 phosphorylation modulates astral microtubule stability to control spindle orientation by Shuang Chen, Ying Hong, Yaping Fang, Mingxuan Li, Jianhong Xia, Jikai Wen, Feiyang Dai, Yuekai Li, Wandi Bu, Michael S. Y. Huen, Jun Jiang, Yiqun Deng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13443627.txt.
Description
Shuang Chen and ten co-authors published a 2026 cell biology study of how dividing cells aim their spindle, the structure that pulls chromosomes apart. Correct aim matters for building organs and keeping tissues healthy. Fibres called astral microtubules anchor the spindle to the cell’s edge to hold it in place.
The team identified a protein, SAPCD2, that steadies these fibres. Removing it made spindles tilt and delayed division. During division, a cell-cycle enzyme tags SAPCD2 at two sites, and that tagged form instead loosens the fibres. Blocking both tags prevented cells from fixing the tilt. The work shows how a timed chemical tag lets cells adjust fibre stability during division.
Catalog record
| CREATOR | Shuang Chen, Ying Hong, Yaping Fang, Mingxuan Li, Jianhong Xia, Jikai Wen, Feiyang Dai, Yuekai Li, Wandi Bu, Michael S. Y. Huen, Jun Jiang, Yiqun Deng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |