ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway
Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu · 2026
Read ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway by Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13443488.txt.
Description
Yu and colleagues uncover a circuit that shields lung cancer cells from a distinctive form of cell death in this 2026 study. The death process, ferroptosis, is driven by iron and damaged fats, and tumors that dodge it grow more freely. The team measured gene and protein levels in lung cancer samples and cells. They focused on two linked factors. One is the stress protein ATF4. The other is the enzyme-building gene SCO2.
Both factors were raised in lung cancer, and ATF4 was shown to bind the SCO2 gene's promoter and switch it on directly. Lowering SCO2 slowed cancer cell growth by triggering ferroptosis, restoring its hallmarks: more lipid reactive oxygen, less glutathione, and more free iron. Blocking the pair also shut down the MAPK growth signaling pathway, and in mice the ATF4-SCO2 axis promoted tumor growth, marking it as a treatment target.
Catalog record
| CREATOR | Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |