LASER couples damage sensing to ESCRT assembly for lysosome repair
Claire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li, Lauren D. Enriquez, Nalan Liv, Laralynne Przybyla, Roberto Zoncu · 2026
Read LASER couples damage sensing to ESCRT assembly for lysosome repair by Claire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li, Lauren D. Enriquez, Nalan Liv, Laralynne Przybyla, Roberto Zoncu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13442042.txt.
Description
Claire S. Goul's team identified LASER in 2026, a protein assembly that couples lysosome damage sensing to repair. Lysosome membrane breaks threaten cell survival, and ESCRT machinery patches them, yet how ESCRT-I recognizes damaged lysosomes was unclear. Genome-wide CRISPR interference screens in damage-sensitive cells found LASER, centered on TFG, which moves to damaged lysosomes upon calcium release by binding ATG8 proteins on lysosomal lipids.
ATG8-bound TFG oligomers recruit the ESCRT-I subunit TSG101, driving sequential ESCRT polymerization and membrane resealing, while disease mutations in TFG that cause hereditary spastic paraplegia break oligomerization and repair. Cell biologists get a complete sensing-to-repair circuit with a neurodegeneration link. The work reframes faulty lysosome repair as a driver of TFG-linked disease.
Catalog record
| CREATOR | Claire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li, Lauren D. Enriquez, Nalan Liv, Laralynne Przybyla, Roberto Zoncu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |