Cortical development dynamics across autism spectrum disorder mouse models
Lena A. Schwarz, Christoph P. Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, Bárbara Oliveira, Matteo Barel, Bernadette Basilico, Chaitanya Chintaluri, Sarah Gorkiewicz, Mohammad Goudarzi, Tereza Belinova, Stephan Reichl, Gintarė Sendžikaitė, Satish Arcot Jayaram, Peter Koppensteiner, Christoph Sommer, Tim P. Vogels, Jörg Menche, Igor Adameyko, Peter V. Kharchenko, Christoph Bock, Gaia Novarino · 2026
Read Cortical development dynamics across autism spectrum disorder mouse models by Lena A. Schwarz, Christoph P. Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, Bárbara Oliveira, Matteo Barel, Bernadette Basilico, Chaitanya Chintaluri, Sarah Gorkiewicz, Mohammad Goudarzi, Tereza Belinova, Stephan Reichl, Gintarė Sendžikaitė, Satish Arcot Jayaram, Peter Koppensteiner, Christoph Sommer, Tim P. Vogels, Jörg Menche, Igor Adameyko, Peter V. Kharchenko, Christoph Bock, Gaia Novarino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13441911.txt.
Description
Lena A Schwarz and a large team profile developing brains across eleven mouse models of autism, hunting for shared biology beneath more than one hundred causal genes, in a 2026 study. Single-nucleus sequencing read both gene activity and chromosome access in 251 samples, spanning both sexes, two brain regions, and three developmental stages. Each model carried a different single-gene fault linked to autism in people.
Despite that variety, mutations converged on the radial glial lineage, the stem-like cells that seed the cortex. The disturbance looked like a passing developmental delay rather than a permanent wrong turn, and it faded by later postnatal stages. Neuron gene changes peaked early after birth, with synaptic and ion channel genes turned down. Electrical recordings matched the molecular story, with altered excitability carrying model-specific flavours. Female mice often showed larger gene effects than males, an angle the authors flag for follow-up.
Catalog record
| CREATOR | Lena A. Schwarz, Christoph P. Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, Bárbara Oliveira, Matteo Barel, Bernadette Basilico, Chaitanya Chintaluri, Sarah Gorkiewicz, Mohammad Goudarzi, Tereza Belinova, Stephan Reichl, Gintarė Sendžikaitė, Satish Arcot Jayaram, Peter Koppensteiner, Christoph Sommer, Tim P. Vogels, Jörg Menche, Igor Adameyko, Peter V. Kharchenko, Christoph Bock, Gaia Novarino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 126501 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |