Augmenting SOFA-2 with immune markers to capture dysregulated host response in patients with suspected infection
Yu Qi, Huihui Sun, Chunhong Hou · 2026
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Description
Yu Qi, Huihui Sun, and Chunhong Hou test whether adding simple immune counts back into a severity score sharpens death prediction in suspected infection, reporting in 2026. The updated SOFA-2 score grades organ failure but leaves the immune system out over specificity worries, even though sepsis means a dysregulated host response to infection. The team analysed 75,203 adults across three large critical care databases. The neutrophil-to-lymphocyte ratio, white cell counts, and lymphocyte counts were folded into the score under agreed, data-driven cutoffs.
The immune-augmented score beat standard SOFA-2 in every cohort, with a significant pooled gain in discrimination. Risk reclassification also improved meaningfully, moving patients into truer risk bands. Gains were modest in size, yet the added markers are cheap and available on routine blood counts. The authors argue that excluding immunity blinds the score to the very process that defines severe infection.
Catalog record
| CREATOR | Yu Qi, Huihui Sun, Chunhong Hou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16917 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |