Comparative efficacy and outcomes of different treatments for pathologically high-risk superficial esophageal cancer: a systematic review and network meta-analysis
Hongzhi He, Hanlu Zhang, Haowen Lv, Ningying Ding, Wenping Wang · 2026
Read Comparative efficacy and outcomes of different treatments for pathologically high-risk superficial esophageal cancer: a systematic review and network meta-analysis by Hongzhi He, Hanlu Zhang, Haowen Lv, Ningying Ding, Wenping Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13441714.txt.
Description
Hongzhi He and colleagues compare treatment strategies for early oesophageal cancer that pathology flags as high risk, pooling studies in a 2026 network meta-analysis. Endoscopic resection can remove superficial cancers, yet tissue checks sometimes reveal traits tied to lymph node spread or return. What to do next, surgery, combined approaches, or other therapy, lacked randomised proof. Searches across four databases to December 2025 found thirty-four studies for the network.
Resection followed by oesophagectomy, full removal of the gullet, gave the most favourable estimates against surgery alone. Gains were clearest for disease-specific and recurrence-free survival, with overall survival pointing the same way short of significance. No other strategy separated clearly from surgery alone. Checks for inconsistency were mostly clean. The authors read the combined route as promising for surgical candidates, while noting that selected retrospective patients limit the claim.
Catalog record
| CREATOR | Hongzhi He, Hanlu Zhang, Haowen Lv, Ningying Ding, Wenping Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54534 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |