The ELAVL1‐PLAUR‐suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation
DanDan Xu, Liang Xu, LinLin Li · 2026
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Description
Xu, Xu, and Li identify a molecular chain that worsens diabetic kidney disease in this 2026 study. Diabetic nephropathy is a leading cause of kidney failure, and its damage centers on podocytes, the cells that wrap the kidney's filters. A circulating factor called suPAR is known to injure podocytes, but what controls its release was unknown. The team studied patient samples, podocytes grown under high sugar, and diabetic mice.
They found the RNA-binding protein ELAVL1 rises in diabetic kidneys and tracks with podocyte injury. ELAVL1 grabs and stabilizes the messenger RNA for PLAUR, raising its protein and thereby suPAR release into the blood. Silencing ELAVL1 protected podocytes, but restoring the PLAUR pathway cancelled that protection. In diabetic mice, podocyte-specific silencing of either link lowered suPAR and eased kidney dysfunction and tissue damage.
Catalog record
| CREATOR | DanDan Xu, Liang Xu, LinLin Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |