N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats
Yixing Fan, Taiyu Hui, Qi Zhang, Ruqing Xu, Jincheng Shen, Yubo Zhu, Man Bai, Wenlin Bai · 2026
Read N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats by Yixing Fan, Taiyu Hui, Qi Zhang, Ruqing Xu, Jincheng Shen, Yubo Zhu, Man Bai, Wenlin Bai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13441224.txt.
Description
Yixing Fan and co-authors trace a molecular chain that steers goat stem cells into hair follicle fate. Their 2026 study works on secondary follicle stem cells from cashmere goats. A circular RNA carrying a chemical tag, m6A, rises after the cells begin to specialize.
Silencing the circle stalled the shift into follicle lines. The tag proved required for the effect, since tag-free mutants failed to rescue the cells. The circle works by soaking up a small RNA that otherwise mutes a key gene. Freed, that gene switches on the Wnt pathway, a master growth signal. The authors map the full chain from tag to fibre.
Catalog record
| CREATOR | Yixing Fan, Taiyu Hui, Qi Zhang, Ruqing Xu, Jincheng Shen, Yubo Zhu, Man Bai, Wenlin Bai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |