mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice
Zahra Akhoond-Ali, Hamed Ghazavi, Mahmoud Hosseini, Masoud Fereidoni, Leyli Polgardani, Ali Nakhaei, Farzaneh Vafaee · 2026
Read mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice by Zahra Akhoond-Ali, Hamed Ghazavi, Mahmoud Hosseini, Masoud Fereidoni, Leyli Polgardani, Ali Nakhaei, Farzaneh Vafaee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13441063.txt.
Description
Zahra Akhoond-Ali and colleagues ask whether bleeding in one mouse brain region reshapes wiring and attention in a distant region, reporting in 2026. The medial prefrontal cortex, a planning hub, talks closely with the hippocampus, a memory hub. Mice received a small haemorrhage in the prefrontal area or a sham operation. Over seventeen days the team graded neurological signs and ran an attentional set-shifting task, which tests how flexibly animals switch rules.
General deficit scores matched between groups, hiding a specific gap. Bleed mice finished fewer task stages and needed more trials, with more rule-loss errors along the way. Tissue staining showed denser dendritic spines, the tiny contact knobs on nerve cells, in hippocampal area CA1 after the bleed, mainly on the right side. White matter stayed unchanged. The authors link remote spine growth to the attention problem and nominate hippocampal plasticity as a recovery target.
Catalog record
| CREATOR | Zahra Akhoond-Ali, Hamed Ghazavi, Mahmoud Hosseini, Masoud Fereidoni, Leyli Polgardani, Ali Nakhaei, Farzaneh Vafaee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |