Ethyl acetate extract of Elephantopus mollis Kunth. induced apoptosis, senescence, and inhibited metastasis-associated traits of human lung cancer cells
Tran Thanh Long, Dang Minh Phuc, Phan Dang Khoi, Dang Thi Phuong Thao, Nguyen Thi My Trinh · 2026
Read Ethyl acetate extract of Elephantopus mollis Kunth. induced apoptosis, senescence, and inhibited metastasis-associated traits of human lung cancer cells by Tran Thanh Long, Dang Minh Phuc, Phan Dang Khoi, Dang Thi Phuong Thao, Nguyen Thi My Trinh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13441040.txt.
Description
Tran Thanh Long and colleagues test extracts of a traditional remedy plant against human lung cancer cells, reporting in 2026. Elephantopus mollis has a folk history in cancer care, and lung cancer remains among the deadliest cancers worldwide. The ethyl acetate extract proved strongest against NCI-H1299 cells at low dose, with notable sparing of other cells. Chemical profiling catalogued its polyphenol content, and cell tests probed how the killing worked.
Treated cells died by programmed suicide through the external death pathway, showed DNA damage, and stalled under a p21-driven cell-cycle brake. Many surviving cells aged into senescence, a first report of both fates from this plant in one line. The extract also cut the cells' crawling, invasion, and grip on collagen, alongside lower output of two spread-linked genes. The authors present the plant as a promising source for anti-cancer chemistry.
Catalog record
| CREATOR | Tran Thanh Long, Dang Minh Phuc, Phan Dang Khoi, Dang Thi Phuong Thao, Nguyen Thi My Trinh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |