Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits
Mahsa P. Yousefkhani, Xiafei Wang, Sara A. Vasilenko · 2026
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Description
Mahsa P. Yousefkhani's team tested executive function in 2026 as a bridge from childhood adversity to teen substance use, using the U.S. ABCD study of over four thousand youths. Adverse childhood experiences predict substance use, yet the brain pathways, and whether deprivation versus threat adversities differ, were understudied. Adversity at ages nine to eleven, executive deficits at twelve to thirteen, and substance use at thirteen to fourteen were modeled in time order.
Executive deficits carried about ten percent of the total adversity effect, fully mediating deprivation adversities and several threat adversities, while sexual abuse showed a direct effect without executive mediation. Prevention teams get a differentiated pathway map: strengthening executive skills may help many adversity-exposed youths, but sexual abuse needs distinct support.
Catalog record
| CREATOR | Mahsa P. Yousefkhani, Xiafei Wang, Sara A. Vasilenko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |