Human Trabecular Meshwork and Hepatocyte Growth Factor
Aparna Rao · 2026
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Description
Rao wrote this 2026 letter about a study by Du and colleagues on hepatocyte growth factor in the eye's drainage tissue. That study asked whether trabecular meshwork stem cells survive a glaucoma-like environment and protect neighboring cells through secreted factors, identifying the growth factor as a mediator. Rao welcomes the work, which used cells from six human donors and a receptor-blocking drug to test causality, but raises methodological cautions for interpretation.
The letter notes that primary meshwork cells change character between culture passages three and five, yet the experiments used cells up to passage six, and asks for passage-matched comparisons. Donor ages spanned 43 to 69 years. Cell numbers and stress tolerance shift across that range. Rao asks whether age was accounted for. She also asks which donor batches served which experiments. The transcriptomic analysis also draws questions as the letter continues.
Catalog record
| CREATOR | Aparna Rao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |