Facile, high‐throughput protein purification enabled by high‐efficiency protease elution
Edson N Cárcamo Noriega, Ian S Truebridge, Frank D Teets, James W Bowman, Nathalia Rodriguez, Tessa A Howard, Christopher D Bahl · 2026
Read Facile, high‐throughput protein purification enabled by high‐efficiency protease elution by Edson N Cárcamo Noriega, Ian S Truebridge, Frank D Teets, James W Bowman, Nathalia Rodriguez, Tessa A Howard, Christopher D Bahl (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13440354.txt.
Description
Edson Cárcamo Noriega and co-authors speed protein purification with a better cutting enzyme, in a 2026 paper. AI has made protein design easy to reach, but making and testing proteins stays a bottleneck. Tags that help purify a protein must be cut off, and past cut based elution gave low yield or left enzyme in the product.
Their new SUMO protease build supports fast, high yield elution from the purification column. The full workflow runs from DNA to protein and was tuned for speed, parallel runs, and broad use, on a robot or by hand. The team made and profiled ninety six unlike proteins as a benchmark set for methods and machine learning.
Catalog record
| CREATOR | Edson N Cárcamo Noriega, Ian S Truebridge, Frank D Teets, James W Bowman, Nathalia Rodriguez, Tessa A Howard, Christopher D Bahl |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |