Early life factors and genetic interactions in allergic rhinitis: a genome-wide study
Shi Huang, Ziyan Zhang, Hongting Zhang, Ke Qiu, Tao Shu, Wei Xu, Juan Meng, Yu Zhao, Jianjun Ren · 2026
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Description
Shi Huang's team studied early life and genes in 2026 in the condition, using UK Biobank and West China Hospital data. Nine early life factors were tested, from birth weight and nursing to germ drugs, C-section birth, and mother's smoking, with gene-setting link scans added. The condition often starts young, yet how early exposures and genes combine was unclear.
Long or repeated childhood germ drugs and C-section birth emerged as independent risk factors in both cohorts. Cesarean risk was confined to girls developing rhinitis before sixteen, and antibiotic effects persisted for later onset. One gene-drug link reached genome mark, and a multi-gene score tracked risk slightly. Allergy teams get early-life targets for prevention research, not proven causes.
Catalog record
| CREATOR | Shi Huang, Ziyan Zhang, Hongting Zhang, Ke Qiu, Tao Shu, Wei Xu, Juan Meng, Yu Zhao, Jianjun Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |