FTO-modulated m6A demethylation and upregulation of KIF11 mRNA promotes retinal microvascular dysfunction in diabetic retinopathy
Chenyu Lin, Chenyang Cao, Shujing Cui, Jinyi Guo, Yu Xin, Jun Shao · 2026
Read FTO-modulated m6A demethylation and upregulation of KIF11 mRNA promotes retinal microvascular dysfunction in diabetic retinopathy by Chenyu Lin, Chenyang Cao, Shujing Cui, Jinyi Guo, Yu Xin, Jun Shao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13439988.txt.
Description
Chenyu Lin's team traced an RNA methylation chain in 2026 driving diabetic retinal vessel dysfunction. The eraser protein FTO is raised in diabetic retinopathy, yet its target genes in retinal vessels were unclear. Vitreous samples from proliferative retinopathy patients were screened for methylation changes, then retinal endothelial cells and diabetic rats were used to test FTO, its target KIF11, and vessel leakage and growth.
FTO removed methylation from KIF11 message, raising KIF11 and promoting endothelial proliferation, migration, and tube formation, with retinal vessel damage in animals tracking the chain. Eye teams get an epitranscriptomic target for diabetic eye disease. Drug blockade of FTO or KIF11 still needs safety and efficacy proof.
Catalog record
| CREATOR | Chenyu Lin, Chenyang Cao, Shujing Cui, Jinyi Guo, Yu Xin, Jun Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |