Cancer-associated fibroblasts in the lung cancer microenvironment from multi-dimensional mechanisms to therapeutic strategies
Yikun Feng, Le Gu, Zhengao Jia, Chunxiao Zhang, Zhengang Zhu · 2026
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Description
Yikun Feng and colleagues review helper cells that shield lung tumours from treatment, focusing on cancer-associated fibroblasts in a 2026 article. Lung cancer still kills more patients than any other cancer, and resistance to drugs is a prime reason. Fibroblasts inside tumours rebuild the tissue scaffold into stiff barriers that block drug entry and switch on survival signals in cancer cells. They also release messenger proteins that push tumours toward spread and blunt immune attack.
Recent single-cell and spatial studies split these fibroblasts into distinct subtypes tied to scaffold building, immune exclusion, and treatment response. Tiny vesicles shed by fibroblasts carry further signals between tumour and immune cells. The review weighs therapies aimed at fibroblast pathways and favours normalising the stroma under biomarker guidance over wiping fibroblasts out wholesale.
Catalog record
| CREATOR | Yikun Feng, Le Gu, Zhengao Jia, Chunxiao Zhang, Zhengang Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73766 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |