The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia
Ilknur Yurtsever, Daniela Farkas, Alex Cornwell, Jessica A Joseph, Siying Xu, Joshua A Englert, Joseph S Bednash, James D Londino, Benjamin S Johnson, Rama K Mallampalli · 2026
Read The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia by Ilknur Yurtsever, Daniela Farkas, Alex Cornwell, Jessica A Joseph, Siying Xu, Joshua A Englert, Joseph S Bednash, James D Londino, Benjamin S Johnson, Rama K Mallampalli (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439470.txt.
Description
Ilknur Yurtsever and colleagues trace how a pneumonia bacterium shields a host protein-destroying machine to weaken lung defences, reporting in 2026. Cells tag proteins with ubiquitin to mark them for disposal, and the ligase part FBXO24 helps choose targets. What guards FBXO24 itself was unknown. In macrophage cell tests, Haemophilus influenzae type B, a pneumonia cause, spared FBXO24 from disposal by cutting its ubiquitin tags.
A cleanup enzyme, USP4, did the untagging after infection, acting through a surface sensor on immune cells. In mouse pneumonia, silencing USP4 or deleting the Fbxo24 gene raised immune cell counts in air spaces while lowering bacterial loads. Lung swelling and injury eased in both cases. The authors show a pathogen exploiting the host's own tag-removal system to blunt innate defence.
Catalog record
| CREATOR | Ilknur Yurtsever, Daniela Farkas, Alex Cornwell, Jessica A Joseph, Siying Xu, Joshua A Englert, Joseph S Bednash, James D Londino, Benjamin S Johnson, Rama K Mallampalli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100870 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |