A narrow developmental window defines PKN2’s essential role in ventricular chamber morphogenesis
Julijus Bogomolovas, Zengming Zhang, Christa Trexler, Alex Campos, Jennifer Veevers, Zeyu Chen, Ju Chen · 2026
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Description
Julijus Bogomolovas and six co-authors trace when a heart protein does its key work as a mouse heart takes shape. The protein, called PKN2, is known to be needed for early heart growth, but the exact window was unclear. Their 2026 study used mice with the protein removed only from heart muscle cells.
Hearts without the protein looked normal at first, then formed an odd pouch-like shape. Gene and protein reads at the key stage showed more cell movement programs and fewer cell division programs. Cell growth slowed just as the shape began to shift. When the protein was removed late, shape stayed normal. The window of need is early and brief, the team finds.
Catalog record
| CREATOR | Julijus Bogomolovas, Zengming Zhang, Christa Trexler, Alex Campos, Jennifer Veevers, Zeyu Chen, Ju Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |