Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C
Cong Wang, Xuexia Xie, Jiahuang Li, Jiawei Zhu, Binghe Sun, Yue Wu, Wanying Zhang, Dake Li, Guo Chen · 2026
Read Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C by Cong Wang, Xuexia Xie, Jiahuang Li, Jiawei Zhu, Binghe Sun, Yue Wu, Wanying Zhang, Dake Li, Guo Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439369.txt.
Description
Cong Wang and colleagues uncover a fuel pathway that helps BRCA1-deficient ovarian cancers spread, publishing in 2026. Faulty BRCA1 is best known for breaking DNA repair in hereditary ovarian cancer. Its part in spread was less clear. Profiling of cell chemistry showed that losing BRCA1 sharply raised choline handling, a nutrient route tied to membrane building. The loss freed a choline transporter, CTL4, by removing a repressive mark that BRCA1 normally helps place on its gene.
Extra transporter activity fed a choline product that steadied FAM3C, a protein that pushes cells toward a mobile state. Blocking the transporter reversed the high spread of deficient cells in tests. A compound named DT-13 curbed choline handling and suppressed spread in the models used. The authors nominate the transporter as a drug target for patients whose tumours carry BRCA1 faults.
Catalog record
| CREATOR | Cong Wang, Xuexia Xie, Jiahuang Li, Jiawei Zhu, Binghe Sun, Yue Wu, Wanying Zhang, Dake Li, Guo Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94552 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |