High glucose impairs autophagy and mitochondrial homeostasis in human dental pulp cells
Zijiang Yang, Xiangzi Zhang · 2026
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Description
Zijiang Yang's team exposed human dental pulp cells in 2026 to high glucose to see how sugar harms tooth pulp through recycling and energy pathways. Dental pulp cells were grown in control, low-glucose, and high-glucose conditions, then checked for viability, reactive oxygen, glutathione, ATP, and key autophagy and energy signals over four days. High glucose is a suspected stressor in diabetic dental disease, but pulp cell mechanisms were incompletely mapped.
High glucose raised a recycling-block marker, lowered a recycling driver, dampened AMPK signaling while raising mTOR signaling, and cut glutathione and ATP while raising reactive oxygen. The pattern points to stalled autophagy and disturbed mitochondrial balance in pulp cells under sugar stress. Dentists get a cellular mechanism linking diabetes to pulp vulnerability.
Catalog record
| CREATOR | Zijiang Yang, Xiangzi Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |