Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut–brain circuit
Hyo Sun Lim, Se Hee Min, Hyo Jin Kim, Chae Beom Park, Seong Jun Kim, Mun Gyeom Kim, Ji Su Kim, Jun Young Byun, Se Eun Park, Myeong Ju Kim, So Yeon Jeong, Jin A. An, Seokbeom Seo, Joomi Park, Yeji Kim, Ji Ye Kim, Sang Ju Lee, Seog-Young Kim, Xin Yi Yeo, Edra London, Jong-Woo Sohn, Gil Myoung Kang, Sangyong Jung, Min-Seon Kim · 2026
Read Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut–brain circuit by Hyo Sun Lim, Se Hee Min, Hyo Jin Kim, Chae Beom Park, Seong Jun Kim, Mun Gyeom Kim, Ji Su Kim, Jun Young Byun, Se Eun Park, Myeong Ju Kim, So Yeon Jeong, Jin A. An, Seokbeom Seo, Joomi Park, Yeji Kim, Ji Ye Kim, Sang Ju Lee, Seog-Young Kim, Xin Yi Yeo, Edra London, Jong-Woo Sohn, Gil Myoung Kang, Sangyong Jung, Min-Seon Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439193.txt.
Description
Hyo Sun Lim and many co-authors trace a brain-to-gut route that curbs sugar uptake from food, in mouse research published in 2026. Brain cells that make POMC, a hormone precursor, help balance body weight and blood sugar. A signalling protein inside them, PKA, switches on after meals and after some modern diabetes drugs. The team forced that signal on in these cells by removing its brake in mice.
The mice grew obese from hormone side effects, yet their blood sugar control improved in a surprising way. Less sugar crossed the gut wall, and more sugar left the body in faeces. Brain signals through the vagus nerve had dialled down SGLT1, the gut's main sugar transporter. The authors suggest the route could inspire diabetes care for people with insulin resistance.
Catalog record
| CREATOR | Hyo Sun Lim, Se Hee Min, Hyo Jin Kim, Chae Beom Park, Seong Jun Kim, Mun Gyeom Kim, Ji Su Kim, Jun Young Byun, Se Eun Park, Myeong Ju Kim, So Yeon Jeong, Jin A. An, Seokbeom Seo, Joomi Park, Yeji Kim, Ji Ye Kim, Sang Ju Lee, Seog-Young Kim, Xin Yi Yeo, Edra London, Jong-Woo Sohn, Gil Myoung Kang, Sangyong Jung, Min-Seon Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75559 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |