Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3
Ana I Moreno-Manuel, Francisco M Cruz, Álvaro Macías, Eva Cabrera-Borrego, José Jalife · 2026
Read Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3 by Ana I Moreno-Manuel, Francisco M Cruz, Álvaro Macías, Eva Cabrera-Borrego, José Jalife (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439188.txt.
Description
Ana I Moreno-Manuel and colleagues test whether natural polyamines can calm a dangerous inherited heart rhythm fault, reporting mouse work in 2026. Short QT syndrome type 3 shortens the heart's electrical reset and raises the risk of sudden death. The fault strengthens a potassium current through Kir2.1 channels, cutting each beat's electrical phase short. No targeted drug exists, so the team tried polyamines, the body's own blockers of those channels.
Male mice carrying the human-like fault showed weak channel control, short QT intervals, and easy triggering of fast ventricle rhythms. Polyamine dosing restored channel behaviour, lengthened the electrical phase and QT interval, and lifted sodium current as well. Treated mice resisted induced rhythm attacks far better. The authors propose polyamines as a lead worth developing for this rare condition.
Catalog record
| CREATOR | Ana I Moreno-Manuel, Francisco M Cruz, Álvaro Macías, Eva Cabrera-Borrego, José Jalife |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84918 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |