Integrated proteomic and metabolomic analyses implicate redox-metabolic pathways in PTSD-associated multisystem disease and accelerated aging
Pei-Fen Kuan, Frank D Mann, Xiaohua Yang, Roman Kotov, Sean Clouston, Olga Ilkayeva, Michael Muehlbauer, Christopher B Newgard, Benjamin J Luft · 2026
Read Integrated proteomic and metabolomic analyses implicate redox-metabolic pathways in PTSD-associated multisystem disease and accelerated aging by Pei-Fen Kuan, Frank D Mann, Xiaohua Yang, Roman Kotov, Sean Clouston, Olga Ilkayeva, Michael Muehlbauer, Christopher B Newgard, Benjamin J Luft (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439172.txt.
Description
Pei-Fen Kuan and co-authors probe blood signals tied to post-traumatic stress disorder and faster ageing, in a 2026 study of World Trade Center responders. Trauma can leave marks far beyond mental health, raising risk for heart, metabolic, and brain disease. The team measured thousands of proteins and a targeted set of small molecules in blood plasma. Their group held 393 responders, 232 with the disorder and 161 who had faced trauma without it.
Over one hundred proteins and seven small molecules differed between the groups. Changed signals clustered around oxidation balance, amino acid handling, immune activity, and nerve cell flexibility. Measures of organ ageing ran ahead in the pancreas and lungs and for the body as a whole. The authors argue that redox and metabolic strain may link trauma to wide-ranging illness over time.
Catalog record
| CREATOR | Pei-Fen Kuan, Frank D Mann, Xiaohua Yang, Roman Kotov, Sean Clouston, Olga Ilkayeva, Michael Muehlbauer, Christopher B Newgard, Benjamin J Luft |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68053 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |