Modular Scalable Synthetic Gene Circuits for Complex Functions Within Minimal Computational Layers in Human Cells
Keren Roas, Ilanit Kovalski, Odelia Mouhadeb, Tamar Aminov, Hadas Weinstein-Marom, Lior Nissim · 2026
Read Modular Scalable Synthetic Gene Circuits for Complex Functions Within Minimal Computational Layers in Human Cells by Keren Roas, Ilanit Kovalski, Odelia Mouhadeb, Tamar Aminov, Hadas Weinstein-Marom, Lior Nissim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13439058.txt.
Description
Keren Roas and colleagues describe a 2026 framework for building gene circuits that do complex jobs inside human cells with fewer steps. Gene circuits act like small programs, yet stacked steps need many parts and drain the cell. The team combined three tools: splicing-based AND gates, promoters that blend natural and synthetic control, and short synthetic RNAs that switch genes off.
With those parts, the group built a three-input logic gate, a half adder, and a full adder. They also built a switch that routes one of three signals and flags an overload state when both selector inputs fire at once. Fewer steps mean smaller genetic loads for each program. Such compact circuits could support future cell therapies, factory cell lines, and basic studies of how cells process signals.
Catalog record
| CREATOR | Keren Roas, Ilanit Kovalski, Odelia Mouhadeb, Tamar Aminov, Hadas Weinstein-Marom, Lior Nissim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86533 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |