Novel fixative solutions with superior preservation of structure and antigenicity are suitable for optical clearing, tissue staining, and flow cytometry
Kumiko Fujieda, Kazuhiro Furuhashi, Kenshi Watanabe, Yuriko Sawa, Akihito Tanaka, Tomohiro Kawazoe, Akiko Owaki, Keita Hattori, Chikao Onogi, Eri Koshi-Ito, Yu Watanabe, Shoichi Maruyama · 2026
Read Novel fixative solutions with superior preservation of structure and antigenicity are suitable for optical clearing, tissue staining, and flow cytometry by Kumiko Fujieda, Kazuhiro Furuhashi, Kenshi Watanabe, Yuriko Sawa, Akihito Tanaka, Tomohiro Kawazoe, Akiko Owaki, Keita Hattori, Chikao Onogi, Eri Koshi-Ito, Yu Watanabe, Shoichi Maruyama (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13438771.txt.
Description
Kumiko Fujieda led a team testing a new tissue fixative in a 2026 study. Fixing tissues is a basic step before lab analysis, but standard chemicals can warp structure and dim glowing labels. Their new solution was compared with standard methods across staining, tissue clearing, and cell sorting tasks.
Staining quality matched the standards, while tissue shape held up better. Clearing let glowing signals be seen deeper inside samples. In sorting tests with glowing cells, the new fixative kept more glow, size, and membrane quality. Human kidney biopsy samples stained as well as with the standard chemical. The authors see wide use for the new solution.
Catalog record
| CREATOR | Kumiko Fujieda, Kazuhiro Furuhashi, Kenshi Watanabe, Yuriko Sawa, Akihito Tanaka, Tomohiro Kawazoe, Akiko Owaki, Keita Hattori, Chikao Onogi, Eri Koshi-Ito, Yu Watanabe, Shoichi Maruyama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |