Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury
Chongjian Wang, Hongkun Ma, Jing Xu, Yan Tang, Jiayin Feng, Yilei Yang, Zhiyu Wang, Wen Zhang · 2026
Read Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury by Chongjian Wang, Hongkun Ma, Jing Xu, Yan Tang, Jiayin Feng, Yilei Yang, Zhiyu Wang, Wen Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13438567.txt.
Description
Wang and co-authors traced how kidney tubule cells in hormone-driven hypertension order neighboring macrophages to self-destruct by inflammatory pyroptosis, a fiery form of cell death. In mice made hypertensive with a salt-and-hormone regimen mimicking aldosterone excess, urinary ATP and the ATP-release channel PANX1 both rose sharply in kidney tissue.
Blocking the hormone receptor with finerenone cut urinary ATP, PANX1 expression, tubule injury, and macrophage inflammation together in the treated animals. Interrupting the signal at any step, the release channel, ATP itself, or its P2X7 receptor on macrophages, likewise eased tubule damage and pyroptosis in the kidney cortex. Co-culture experiments confirmed tubule cells under hormone stimulation drove macrophage death and migration, reversible by silencing the channel in the tubule cells. Single-cell sequencing verified the pathway's activation in real kidney macrophages.
Catalog record
| CREATOR | Chongjian Wang, Hongkun Ma, Jing Xu, Yan Tang, Jiayin Feng, Yilei Yang, Zhiyu Wang, Wen Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |