Clinical equipoise and ethical challenges in expanding endovascular stroke thrombectomy practice
Aryan Wadhwa, Evan P. McNeil, Pratham B. Bhatt, Kimberly Han, Shashvat Purohit, Justin Granstein, Christopher S. Ogilvy, Mario Ganau, Philipp Taussky · 2026
Read Clinical equipoise and ethical challenges in expanding endovascular stroke thrombectomy practice by Aryan Wadhwa, Evan P. McNeil, Pratham B. Bhatt, Kimberly Han, Shashvat Purohit, Justin Granstein, Christopher S. Ogilvy, Mario Ganau, Philipp Taussky (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438443.txt.
Description
Aryan Wadhwa and co-authors examined the ethics of trials that proved clot removal for stroke. Pulling a clot from a blocked brain artery, called thrombectomy, helps many patients, yet testing it meant randomizing people who often could not consent, with minutes deciding outcomes. Their 2026 analysis read the practice-changing trials and ethics literature from 2003 to 2024 across three pressure points.
After 2015 the proof piled up so fast that honest doubt collapsed, and several trials stopped early to spare the control group, at some cost to the precision of their estimates. Standard consent, signed by patient or family, also skewed who entered: the most severe cases, often voiceless, were shut out. The authors back deferred or presumed consent for such emergencies, arguing that rigid respect for autonomy can breach fairness by excluding the most vulnerable from research on their own rescue.
Catalog record
| CREATOR | Aryan Wadhwa, Evan P. McNeil, Pratham B. Bhatt, Kimberly Han, Shashvat Purohit, Justin Granstein, Christopher S. Ogilvy, Mario Ganau, Philipp Taussky |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24358 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |