Art an 3 as a candidate recombinant antigen for Artemisia pollen immunotherapy: comparative efficacy and mechanistic insights
Jiacheng Shen, Tao Wang, Bin Zhou, Bowen Tian, Binhao Liu, Jiachen Gui, Yue Zhang, Wenzhi Hu, Yuting Lai, Honghao Zhang, Qiang Li · 2026
Read Art an 3 as a candidate recombinant antigen for Artemisia pollen immunotherapy: comparative efficacy and mechanistic insights by Jiacheng Shen, Tao Wang, Bin Zhou, Bowen Tian, Binhao Liu, Jiachen Gui, Yue Zhang, Wenzhi Hu, Yuting Lai, Honghao Zhang, Qiang Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438400.txt.
Description
Jiacheng Shen and colleagues tested a lab-made single allergen against the crude pollen extract now used to retrain the immune systems of people allergic to Artemisia. Their 2026 study worked in female mice made asthmatic with mugwort pollen. Groups received the standard extract, the recombinant allergen Art an 3, or a dummy treatment. The team then read airway sensitivity, lung tissue, wash fluid, blood antibodies, and immune cell mixes.
The extract edged ahead on tissue healing and cut allergy-linked cells and antibodies more clearly. The single allergen answered with a different signature: it raised calming signals and grew more regulatory and helper T cells of the protective kind, plus more blocking antibody. The authors judge the defined molecule roughly the extract's equal in protection, with a tidier, more standardizable makeup. That profile makes Art an 3 a serious candidate for the next generation of allergy shots, pending human trials.
Catalog record
| CREATOR | Jiacheng Shen, Tao Wang, Bin Zhou, Bowen Tian, Binhao Liu, Jiachen Gui, Yue Zhang, Wenzhi Hu, Yuting Lai, Honghao Zhang, Qiang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40819 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |