The interplay of the microbiome, host genetics, and epigenetic modifications in gastric cancer
Ting Zhou, Guona Li, Wujie Ye, Luyi Wu, Huirong Liu, Jing Guo, Yunfan Wen, Jing Li, Mengdie Wu, Weiwei Li, Huangan Wu · 2026
Read The interplay of the microbiome, host genetics, and epigenetic modifications in gastric cancer by Ting Zhou, Guona Li, Wujie Ye, Luyi Wu, Huirong Liu, Jing Guo, Yunfan Wen, Jing Li, Mengdie Wu, Weiwei Li, Huangan Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438386.txt.
Description
Ting Zhou and a large team review gastric cancer as the product of a three-way conversation among gut microbes, inherited genes, and epigenetic marks, chemical tags tuning genes without changing their code. Stomach cancer ranks among the world's deadliest cancers. The bacterium Helicobacter pylori, carried by half of humanity, is a proven driver, yet genes and habits decide who falls ill.
The circuit runs both ways. A person's genes and epigenetic settings shape which microbes settle in the stomach. Those microbes and their products then rewrite epigenetic marks, switching cancer genes on and tumor guards off. Epstein-Barr virus, salty diets, smoking, and alcohol feed into the same web. Walking through each strand and their crossings, the review assembles targets for prevention and treatment that single-lens research misses. The authors frame the triad as the field's organizing puzzle: decode the conversation, and precise intervention gets closer.
Catalog record
| CREATOR | Ting Zhou, Guona Li, Wujie Ye, Luyi Wu, Huirong Liu, Jing Guo, Yunfan Wen, Jing Li, Mengdie Wu, Weiwei Li, Huangan Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54097 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |