Plasma p‐tau217 detects Alzheimer's disease co‐pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort
Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Rosa María Manero‐Borràs, Laura Ludovica Gramegna, Marc Viles, Ana Rodríguez Campello, Paula Ortiz‐Romero, Marina de Diego, Marta del Campo, Javier Torres‐Torronteras, Esther Jiménez‐Moyano, Helena Blasco‐Forniés, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez · 2026
Read Plasma p‐tau217 detects Alzheimer's disease co‐pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort by Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Rosa María Manero‐Borràs, Laura Ludovica Gramegna, Marc Viles, Ana Rodríguez Campello, Paula Ortiz‐Romero, Marina de Diego, Marta del Campo, Javier Torres‐Torronteras, Esther Jiménez‐Moyano, Helena Blasco‐Forniés, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438190.txt.
Description
Fernández‐Lebrero and a large team test a blood marker in patients with a brain vessel disease in this 2026 study. Cerebral amyloid angiopathy deposits amyloid in brain blood vessels and often overlaps with Alzheimer's disease. The blood marker p-tau217 is a strong indicator of Alzheimer's, but whether it still works when vessel disease is present was unclear. The team studied 231 people, including 50 with the vessel disease and 154 with Alzheimer's.
Among the vessel-disease patients, 29 also met spinal fluid criteria for Alzheimer's. The blood marker separated those with and without the overlap very well. It scored a discrimination value of about 0.92 in this cohort's analysis, a strong result. The marker showed no relationship to scan measures of vessel disease severity, supporting that it reflects Alzheimer's pathology specifically. Two pre-set cut-off values both identified the overlap accurately.
Catalog record
| CREATOR | Aida Fernández‐Lebrero, Joan Jiménez‐Balado, Greta García‐Escobar, José Contador, Isabel Estraguès‐Gázquez, Laia Peraferrer‐Montesinos, Rosa María Manero‐Borràs, Laura Ludovica Gramegna, Marc Viles, Ana Rodríguez Campello, Paula Ortiz‐Romero, Marina de Diego, Marta del Campo, Javier Torres‐Torronteras, Esther Jiménez‐Moyano, Helena Blasco‐Forniés, Marc Suárez‐Calvet, Angel Ois, Albert Puig‐Pijoan, Irene Navalpotro‐Gómez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |