Mapping immune responses to TAK-003 dengue vaccine: immunogenicity across the clinical development program
Sanja Mandaric, Tarek El Hindi, Eduardo J. M. Nascimento, Xavier Saez-Llorens, Charissa Borja-Tabora, Heather Friberg, Vianney Tricou, Nicholas Roubinis, Raphael Gottardo, Jeffrey R. Currier, Mayuri Sharma, Shibadas Biswal · 2026
Read Mapping immune responses to TAK-003 dengue vaccine: immunogenicity across the clinical development program by Sanja Mandaric, Tarek El Hindi, Eduardo J. M. Nascimento, Xavier Saez-Llorens, Charissa Borja-Tabora, Heather Friberg, Vianney Tricou, Nicholas Roubinis, Raphael Gottardo, Jeffrey R. Currier, Mayuri Sharma, Shibadas Biswal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438160.txt.
Description
Sanja Mandaric led a twelve-author summary of immune responses to TAK-003, a live weakened vaccine against all four dengue virus types. Dengue vaccine design is notoriously hard, since partial immunity can worsen a later bout. Across the trial program, volunteers who had never met dengue and those who had were tested in endemic and non-endemic regions. Their 2026 review gathers the size, quality, and power of the antibody and cell responses after each dose.
The vaccine is built on a type 2 backbone dressed with parts of other types, and responses differed by type, age, and region. The review tracks how long protection signals persist, which immune marks predict real protection. No single marker yet certifies protection for dengue, which is why this wide immune map matters. It gives regulators and doctors the fullest available picture of what the vaccine stirs while outcome data keep accumulating.
Catalog record
| CREATOR | Sanja Mandaric, Tarek El Hindi, Eduardo J. M. Nascimento, Xavier Saez-Llorens, Charissa Borja-Tabora, Heather Friberg, Vianney Tricou, Nicholas Roubinis, Raphael Gottardo, Jeffrey R. Currier, Mayuri Sharma, Shibadas Biswal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71999 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |