AOC1 regulates labor initiation through spermidine-induced autophagy of placental trophoblast cells via EIF5A hypusination
Huaiyan Chen, Peihua Long, Zhe Wang, Ruoheng Du, Chagui Zheng, Zhuo Li, Yihuan Xu, Qiaozhen Peng, Xuesong Sui, Yanyu Sui, Xiang Jiang, Qin Li, Lu Gao · 2026
Read AOC1 regulates labor initiation through spermidine-induced autophagy of placental trophoblast cells via EIF5A hypusination by Huaiyan Chen, Peihua Long, Zhe Wang, Ruoheng Du, Chagui Zheng, Zhuo Li, Yihuan Xu, Qiaozhen Peng, Xuesong Sui, Yanyu Sui, Xiang Jiang, Qin Li, Lu Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13438134.txt.
Description
Huaiyan Chen and a large team uncovered a placental switch that helps time the start of labor. Birth timing depends on mother and fetus talking to each other, and the placenta's part was murky. Studying mice lacking two helper proteins for hormone signaling, their 2026 paper traces a chain in the placenta. Enzyme AOC1 falls, spermidine rises, and a tagged protein switches on a self-cleaning program in placenta cells.
That cleaning program lowers the placenta's output of estrogen and prostaglandins, two labor drivers. Estrogen in turn raises AOC1, closing a feedback loop that keeps the system in balance. Deleting the enzyme in the placenta delayed labor sharply by letting the cleaning program run hot. Most striking, giving spermidine rescued mice from inflammation-driven early labor. The authors offer the chain as a new account of how birth is timed, and spermidine as a candidate guard against preterm birth.
Catalog record
| CREATOR | Huaiyan Chen, Peihua Long, Zhe Wang, Ruoheng Du, Chagui Zheng, Zhuo Li, Yihuan Xu, Qiaozhen Peng, Xuesong Sui, Yanyu Sui, Xiang Jiang, Qin Li, Lu Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98450 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |