Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei · 2026
Read Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms by Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437931.txt.
Description
Oraegbuna and colleagues probe how the hunger hormone ghrelin sharpens a memory-related brain circuit in this 2026 study. Ghrelin's receptors are densely expressed on granule cells in the dentate gyrus. That region is a hippocampal gateway for spatial memory. But the receptors' function there was not fully understood. Using electrical recordings from individual cells and a Y-maze test of short-term spatial memory in mice, the team traced ghrelin's effects channel by channel.
Ghrelin excited the granule cells by closing two kinds of potassium channel and opening sodium and HCN channels, making the cells fire more readily. The effect required the signaling molecules adenylyl cyclase and EPAC2 but not two other common pathways. Overnight fasting naturally raised cell excitability through the same receptors, and injecting ghrelin into the region improved the mice's alternation behavior in the maze.
Catalog record
| CREATOR | Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |