The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla · 2026
Read The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens by Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437925.txt.
Description
Sewa, Yang, and Khosla review a newly recognized route by which modified food proteins become immune targets in this 2026 article. Chemical alterations to proteins can create neo-epitopes, new shapes the immune system has not learned to tolerate. In celiac disease, the enzyme transglutaminase 2 converts a specific amino acid in gluten fragments. That makes the fragments bind strongly to HLA-DQ2. This molecule presents them to T cells.
The puzzle was delivery: such modified fragments are scarce in the gut lining, yet dendritic cells capture them efficiently. The review explains that the enzyme-fragment complex docks onto a receptor called LRP1, which ferries it into the cell's processing compartments and releases the altered fragment there. A similar alteration-driven mechanism may operate in rheumatoid arthritis, and the authors discuss exploiting this selective pathway in vaccine design.
Catalog record
| CREATOR | Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |