Non-coding RNA-driven cardiovascular immunometabolic reprogramming: from inflammatory endotypes to therapeutic opportunities
Yang Sheng, Yao Yao, Hengcang Wang · 2026
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Description
Yang Sheng, Yao Yao, and Hengcang Wang argue heart and vessel disease should be read as an immune and metabolic disorder steered partly by non-coding RNA. These RNA strands never build proteins, yet they tune gene activity across many cell types. Their 2026 review sorts patients by dominant mechanism rather than by disease label alone, sketching types such as artery inflammation, sterile injury, and fibro-inflammatory remodeling.
Short and long RNA species, plus ring-shaped ones, govern cholesterol handling in macrophages, inflammation alarms, vessel lining activation, and heart muscle scarring. The same molecule can protect in one cell and harm in another, which defeats simple good-versus-bad labels. Spilled RNA in blood could serve as a liquid biopsy, and RNA-based drugs are in reach. They frame the endotypes as research tools, not clinic tests, until trials sort patients by them and prove the sorting helps.
Catalog record
| CREATOR | Yang Sheng, Yao Yao, Hengcang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74186 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |