IL-33 promotes efferocytosis by peritoneal macrophages by a mechanism associated with rapid granulocyte IL-13 production
Stephanie A. Legere, Roopa Hebbandi Nanjundappa, Dihia Meghnem, Ian D. Haidl, Alexander Edgar, Qianni Hu, Jean-François Légaré, Jean S. Marshall · 2026
Read IL-33 promotes efferocytosis by peritoneal macrophages by a mechanism associated with rapid granulocyte IL-13 production by Stephanie A. Legere, Roopa Hebbandi Nanjundappa, Dihia Meghnem, Ian D. Haidl, Alexander Edgar, Qianni Hu, Jean-François Légaré, Jean S. Marshall (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437444.txt.
Description
Stephanie Legere and colleagues show how a danger signal called IL-33 helps the body clean up dead cells after inflammation. Clearing spent cells, called efferocytosis, falls to macrophages armed with a surface receptor named MerTK. Their 2026 mouse study injected IL-33 into the belly cavity and watched the local immune scene over two days.
Within forty-eight hours, MerTK-carrying macrophages grew more numerous and ate dead cells faster when tested. IL-13 appeared in cavity fluid soon after the injection, before lymphocyte groups showed any change. Mast cells proved a major early source: mice bred without them made far less IL-13 three hours after treatment, while mice lacking eosinophils matched normal levels. Lab cultures confirmed mast cells can answer IL-33 within hours. The authors link the chain to human care, settings with high levels of a decoy receptor for IL-33, or with few mast cells, tend to fare worse.
Catalog record
| CREATOR | Stephanie A. Legere, Roopa Hebbandi Nanjundappa, Dihia Meghnem, Ian D. Haidl, Alexander Edgar, Qianni Hu, Jean-François Légaré, Jean S. Marshall |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43412 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |