UAP1 as a prognostic biomarker regulating malignant biological functions in multiple myeloma cells
Xiang Li, Changjian Yan, Lihua Lu, Xiaoyu Wei, Qing Cai, Yanxin Chen, Jianda Hu · 2026
Read UAP1 as a prognostic biomarker regulating malignant biological functions in multiple myeloma cells by Xiang Li, Changjian Yan, Lihua Lu, Xiaoyu Wei, Qing Cai, Yanxin Chen, Jianda Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437300.txt.
Description
Xiang Li and colleagues examine a gene called UAP1 as a warning marker and possible drug target in multiple myeloma, a plasma cell cancer of the marrow. The gene helps build sugar-coated proteins, and it fuels growth in several other cancers. Their 2026 study mined six data sets covering 3,117 patients, plus single-cell readings and tests in two myeloma cell lines.
Patients whose tumors made more UAP1 died sooner and relapsed faster on every survival measure the team used. Single-cell data placed UAP1 mainly inside tumor cells, tied to how far those cells had matured and to signals that mute the immune system. In the lab, switching the gene off slowed cell growth, pushed cells toward death, and made them more sensitive to a standard steroid drug. The authors present UAP1 as a sign of worse outlook and a lever future treatments might pull.
Catalog record
| CREATOR | Xiang Li, Changjian Yan, Lihua Lu, Xiaoyu Wei, Qing Cai, Yanxin Chen, Jianda Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51693 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |