From anatomical to biological resectability: navigating adaptive resistance in hepatocellular carcinoma conversion
Shitao Lei, Yun Cong, Yuhang Yang, Yaoqiang Bao, Wei Huang, Yingmei Shao · 2026
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Description
Shitao Lei and co-authors argue that judging liver cancer surgery by tumor size alone misses the deeper question of whether the cancer has truly been tamed. Conversion therapy uses drugs and local treatments to shrink tumors once thought beyond surgery. Their 2026 piece proposes a shift from anatomical resectability, whether the tumor can be cut out, to biological resectability, whether its behavior makes surgery worthwhile.
Strong treatment pressure can backfire, the authors warn. It may drive hidden tumor clones to adapt and resist, through growth signals or shifts in how cells fuel themselves. Early signs suggest good downsizing also warms the tumor's immune surroundings, drawing in killer T cells. They propose measurable tests for the new standard, such as cleared tumor DNA in blood and mature immune clusters in tissue. The framework is provisional, built to help doctors time surgery and catch resistance early.
Catalog record
| CREATOR | Shitao Lei, Yun Cong, Yuhang Yang, Yaoqiang Bao, Wei Huang, Yingmei Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48558 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |