Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA
Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner · 2026
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Description
Cadet and colleagues review how one-electron oxidation damages DNA bases in this 2026 survey. Certain light-activated compounds, carbonate radicals, and intense ultraviolet lasers can strip a single electron from the purine and pyrimidine building blocks of DNA. The resulting charged bases shed protons or attract other molecules. The authors gathered evidence on what happens to them. They covered model systems and living cells.
The damage concentrates overwhelmingly at guanine bases, producing a signature lesion called 8-oxo-7,8-dihydroguanine, even when the initial hit lands elsewhere on the DNA strand. The explanation is hole migration: the positive charge travels along the double helix until it settles at guanine, the easiest base to oxidize. Because cellular DNA shows the same pattern, the authors argue direct effects explain only a modest share of radiation's oxidative damage.
Catalog record
| CREATOR | Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |