Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation
Patrick Terrence Brooks, Lia Minculescu, Hans Jakob Hartling, Rebecca Svanberg Teglgaard, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Jens Lundgren, Susanne Dam Nielsen, Lars Klingen Gjærde, Hanne Vibeke Marquart, He · 2026
Read Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation by Patrick Terrence Brooks, Lia Minculescu, Hans Jakob Hartling, Rebecca Svanberg Teglgaard, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Jens Lundgren, Susanne Dam Nielsen, Lars Klingen Gjærde, Hanne Vibeke Marquart, He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13437226.txt.
Description
Patrick Terrence Brooks's team profiled early immune recovery in 2026 among seventy-seven adults one month after donor stem cell transplant. Post-transplant troubles are largely immune-driven, so a day twenty-eight blood profile may flag who thrives, relapses, or develops graft-versus-host disease. High-resolution cell typing plus cytokine release after stimulation mapped innate and adaptive compartments, activation, and checkpoint markers.
Higher overall immune counts and stronger cytokine responses went with better survival. Stronger innate subsets went with less relapse, while high PD-1 on helper T cells and activation on killer T cells went with poorer survival. Transplant teams get an early, functional snapshot for monitoring and for picking immune targets. Validation in larger groups is needed before clinical use.
Catalog record
| CREATOR | Patrick Terrence Brooks, Lia Minculescu, Hans Jakob Hartling, Rebecca Svanberg Teglgaard, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Jens Lundgren, Susanne Dam Nielsen, Lars Klingen Gjærde, Hanne Vibeke Marquart, He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |