Time to resolution of veno-occlusive disease/sinusoidal obstruction syndrome post-HCT in defibrotide-treated adults from two European registries
Mohamad Mohty, Régis Peffault de Latour, Myriam Labopin, Vian Amber, Amélie Petitprez, Deborah Gutierrez, Nalina Dronamraju, Hélène Labussière-Wallet, Didier Blaise · 2026
Read Time to resolution of veno-occlusive disease/sinusoidal obstruction syndrome post-HCT in defibrotide-treated adults from two European registries by Mohamad Mohty, Régis Peffault de Latour, Myriam Labopin, Vian Amber, Amélie Petitprez, Deborah Gutierrez, Nalina Dronamraju, Hélène Labussière-Wallet, Didier Blaise (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437224.txt.
Description
Mohamad Mohty led a pooled look at two European registries tracking defibrotide, a drug used for a dangerous liver complication after stem cell transplant. The condition, called veno-occlusive disease, blocks small liver veins and can kill if untreated. Their 2026 report covers 275 adults, of whom 215 had severe disease and sixty had milder forms.
Median time to clearing was about eighteen and a half days for severe cases and about sixteen and a half days for milder ones. Among patients whose disease cleared, nearly a third in each group needed more than twenty-one days of treatment. Survival at day one hundred after transplant reached 82 percent overall among those who cleared, higher in milder cases. Serious side effects appeared in 31 percent of the cleared group. The authors read the record as support for the drug, noting that stopping at three weeks would cut many courses short.
Catalog record
| CREATOR | Mohamad Mohty, Régis Peffault de Latour, Myriam Labopin, Vian Amber, Amélie Petitprez, Deborah Gutierrez, Nalina Dronamraju, Hélène Labussière-Wallet, Didier Blaise |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35600 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |