Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo · 2026
Read Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice by Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13437094.txt.
Description
Dalle and colleagues chart fat-like signaling molecules in the muscles of ALS model mice in this 2026 study. Amyotrophic lateral sclerosis wastes muscle, and the endocannabinoid system, which helps regulate muscle maintenance, had never been studied inside ALS muscle. The team compared a fast-twitch leg muscle and a slow-twitch one in female mice before and after symptoms, and checked human ALS muscle data as well.
The fast muscle lost about three-quarters of its mass. The slow muscle shrank only modestly. The lipid upheaval matched that divide. Far more mediators changed in the fast muscle. Anandamide, an endocannabinoid, rose by over a third there, and its receptor nearly doubled, with changes visible before symptoms and mirrored in human samples. Yet a drug blocking the system's breakdown enzyme improved neither movement nor survival.
Catalog record
| CREATOR | Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |