Astragalin Suppresses Colorectal Carcinogenesis by Targeting Proliferation, Oxidative Stress, and Inflammation
Suhayla Hamad Shareef, Haween Toufiq Nanakaly, Salam Adil Ahmed, Noor Ali Gheni, Derin Nabaz Fisal, Nabaz Fisal Shakir Agha, Mahmood Ameen Abdulla · 2026
Read Astragalin Suppresses Colorectal Carcinogenesis by Targeting Proliferation, Oxidative Stress, and Inflammation by Suhayla Hamad Shareef, Haween Toufiq Nanakaly, Salam Adil Ahmed, Noor Ali Gheni, Derin Nabaz Fisal, Nabaz Fisal Shakir Agha, Mahmood Ameen Abdulla (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13436567.txt.
Description
Shareef and colleagues tested in 2026 whether astragalin, a plant compound, can slow colorectal cancer in lab dishes and in rats. Colorectal cancer is a leading cause of cancer death, and plant compounds are a steady source of candidate preventive drugs. The team measured growth of two human colon cancer cell lines and early precancerous changes in rat colons.
Astragalin slowed both cell lines at modest doses. In rats given a cancer-causing chemical, two months of the compound cut early abnormal crypt clusters and improved colon tissue structure. It also lowered a key growth signal while raising a cell-death signal. It also boosted antioxidant defenses and calmed inflammation signals. The authors conclude the compound shows preventive promise, while noting animal findings are an early step.
Catalog record
| CREATOR | Suhayla Hamad Shareef, Haween Toufiq Nanakaly, Salam Adil Ahmed, Noor Ali Gheni, Derin Nabaz Fisal, Nabaz Fisal Shakir Agha, Mahmood Ameen Abdulla |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |