CPNE1 promotes stemness and confers resistance to GPC3 CAR-T cell therapy in hepatocellular carcinoma via the STAT3–TGF-β signaling pathway
Hao Zhang, Tong Xiang, Qiuzhong Pan, Mengjia Song, Lili Huang, Yao-Jun Zhang, Zili Hu, Xinyi Yang, Haoran Zhong, Yingzi Li, Jun Luo, Hao Chen, Song Gao, Chaopin Yang, Jian-Chuan Xia · 2026
Read CPNE1 promotes stemness and confers resistance to GPC3 CAR-T cell therapy in hepatocellular carcinoma via the STAT3–TGF-β signaling pathway by Hao Zhang, Tong Xiang, Qiuzhong Pan, Mengjia Song, Lili Huang, Yao-Jun Zhang, Zili Hu, Xinyi Yang, Haoran Zhong, Yingzi Li, Jun Luo, Hao Chen, Song Gao, Chaopin Yang, Jian-Chuan Xia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13436198.txt.
Description
Hao Zhang and colleagues pinpoint a protein, CPNE1, that helps liver cancer grow, stay stem-like, and resist a cell therapy. The therapy retrains a patient's own immune cells to attack a marker called GPC3 on liver cancer cells.
CPNE1 ran high in liver tumours and tracked with poor survival for patients. In lab and mouse studies, it switched on a signalling chain that raised growth and stem-like traits in the cancer cells. The chain also pushed the cancer to release a factor that tires out the engineered immune cells. Silencing CPNE1 restored those cells, drew more of them into tumours, and improved tumour control without body-wide harm.
Catalog record
| CREATOR | Hao Zhang, Tong Xiang, Qiuzhong Pan, Mengjia Song, Lili Huang, Yao-Jun Zhang, Zili Hu, Xinyi Yang, Haoran Zhong, Yingzi Li, Jun Luo, Hao Chen, Song Gao, Chaopin Yang, Jian-Chuan Xia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |