Methodological considerations for the establishment of epidemiological cutoff values for Sporothrix species using CLSI broth microdilution
Guanghui Chen, Yang Zou, Keqian Chen · 2026
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Description
Guanghui Chen, Yang Zou, and Keqian Chen caution that cutoff values for Sporothrix fungi may rest on flawed test heat in 2026. Standard broth tests run at thirty five degrees, which pushes the fungus to shift form mid test. Mixed forms skew the drug levels that set wild type cutoffs.
Yeast form fungi can read eight fold lower drug levels than the thread form. Rejected data sets ran seventeen to thirty percent for one species, the letter notes. A terbinafine cutoff for a second species rests on just thirty eight isolates with a split pattern. The authors urge retesting at thirty degrees before cutoffs harden into clinic rules.
Catalog record
| CREATOR | Guanghui Chen, Yang Zou, Keqian Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3267 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |