Macrophage polarization-related genes with potential causal roles in osteoporosis: a multi-omics Mendelian randomization study
Feng Xiong, Aoqi Zang, Ming Zhu, Bingxu Ma, Jun Zhang, Peitai Liu, Feng Qian, Jianzhong Guan, Hui Xu · 2026
Read Macrophage polarization-related genes with potential causal roles in osteoporosis: a multi-omics Mendelian randomization study by Feng Xiong, Aoqi Zang, Ming Zhu, Bingxu Ma, Jun Zhang, Peitai Liu, Feng Qian, Jianzhong Guan, Hui Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13435712.txt.
Description
Feng Xiong, Aoqi Zang, Ming Zhu, and a wider team wrote this research paper, published in 2026. It hunts for genes that may cause osteoporosis, the bone-thinning disease, focusing on genes tied to how immune cells called macrophages switch between states.
The team used a genetics method that links inherited variants to gene activity, chemical marks on DNA, and protein levels, then checks those against large osteoporosis datasets. The scan flagged dozens of candidate genes. A few stood out across several data layers, among them DNMT3A, CTSK, AGER, and HMOX1. The authors also checked gene activity in thigh bone tissue from patients and controls. The results give drug and biology researchers a short list of genes worth testing as real drivers of bone loss.
Catalog record
| CREATOR | Feng Xiong, Aoqi Zang, Ming Zhu, Bingxu Ma, Jun Zhang, Peitai Liu, Feng Qian, Jianzhong Guan, Hui Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |