L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis
Jin Suk Park, Yasemin Kaygusuz, Carson Kenum, Lan He, Mohamed I. Gatie, Xueqian Zhuang, Roshan Sharma, Ronan Chaligné, Umesh K. Bhanot, Richard P. Koche, Tuomas Tammela, Anna-Katerina Hadjantonakis, Charles M. Rudin, Joan Massagué · 2026
Read L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis by Jin Suk Park, Yasemin Kaygusuz, Carson Kenum, Lan He, Mohamed I. Gatie, Xueqian Zhuang, Roshan Sharma, Ronan Chaligné, Umesh K. Bhanot, Richard P. Koche, Tuomas Tammela, Anna-Katerina Hadjantonakis, Charles M. Rudin, Joan Massagué (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434761.txt.
Description
Jin Suk Park and a large team trace how lung tumors make roaming seed cells in 2026. Tumor edge cells wear a sticky protein, L1CAM, also seen on healing lung cells. The protein turns out to build the seed state itself, not just mark it.
At cell borders L1CAM gathers a polarity complex that fires a side branch of Wnt signals. That branch wakes a factor that, with a DNA unwinding partner, switches on SOX2. It keeps the seed state and its spread power alive. Cutting the chain may stall spread at its source. Distant tumor sites wear the same marks.
Catalog record
| CREATOR | Jin Suk Park, Yasemin Kaygusuz, Carson Kenum, Lan He, Mohamed I. Gatie, Xueqian Zhuang, Roshan Sharma, Ronan Chaligné, Umesh K. Bhanot, Richard P. Koche, Tuomas Tammela, Anna-Katerina Hadjantonakis, Charles M. Rudin, Joan Massagué |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 126417 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |